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Legal gray area: Not approved for medical use

The single completed human trial by Sikiri et al

A comprehensive treatment strategy that also includes dietary modifications, the use of additional drugs, and the use of nutritional supplements may only include a tiny fraction of this medication

Geriatr Gerontol Int 2023;23(5):366370

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Therefore, deficiencies of B group vitamins can develop rapidly if any of the following conditions are present: reduced food intake, gastro-intestinal disturbances (reducing synthesis and absorption), liver damage preventing mobilization of reserves and heavy demands on tissue repair/metabolism requirements