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Management of ARIA may include discontinuation of the medication either temporarily or indefinitely To ensure that ARIA is identified should it occur, the appropriate use recommendations (AUR, i.e., guidelines for clinicians to administer new therapies safely and effectively) for lecanemab suggest health care professionals obtain MRI scans of the brain before the 5th, 7th, 14th and 26th infusions, in addition to a baseline scan before starting treatment

However, 2-3 months after injection, the benefits of the local anaesthetic injection were reducing and the improvements in the Botox injection group were increasing

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This concern has not been studied longitudinally even in animal models the existing preclinical studies used relatively short treatment durations

Orthopedics 35 , e175e178 (2012)