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GSH therefore has a dual role in the inflammatory response as an antioxidant ROS scavenger in the oxidative stress as well as signaling molecule that regulates protein function through thioldisulfide exchange reactions such as protein glutathionylation with many examples of regulation of oncogenes (e.g., p53, HIF-1, c-jun) presented in the database developed by Chen et al., [104] as well as in a recent review [105]

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doi: 10.1097/01.hjh.0000160216.86597.ff 201

This indicates that hydrogen water may provide symptomatic relief for early-stage PD patients, suggesting its potential as a therapeutic adjunct