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A systematic review of 35 prospective cohort studies assessing the association between vitamin B 12 status and cognitive deterioration in older individuals with or without dementia at baseline did not support a relationship between serum vitamin B 12 concentrations and cognitive decline, dementia, or Alzheimers disease (79)

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including 768 healthy controls, 133 patients with mild cognitive impairment, and 211 Alzheimer disease patients) found a U-shaped relation between RBC folate and plasma tHcy, such that higher tHcy was observed with the lowest and highest RBC folate concentrations compared with intermediate concentrations

Based on clinical observations, some people might experience mild side effects

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Its a state-of-the-art multivitamin using nature-identical vitamins and minerals for optimal absorption and bioactivities