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This is a valid concern with GLP-1 **weight loss peptides** approximately 25-40% of weight lost with semaglutide comes from lean mass

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Vitamin B12 therefore has a central, hormone-like effect in the nervous system

Abstract In the SELECT cardiovascular outcomes trial, semaglutide showed a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes

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