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Another comparison trial exploring vitamin B12 alone compared to vitamin B12 with acupuncture for chemotherapy-induced peripheral neuralgia in multiple myeloma showed benefits in pain reduction as well

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Detoxification and Cleansing: Methionine also plays a role in detoxification

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In contrast, it would appear that the neurologic effects of cobalamin deficiency are due to metabolic disturbances unrelated to purine synthesis because the neurologic deficits may develop independently of the hematologic abnormalities, and folate supplementation will not prevent or reverse these deficits