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elegans lifespan, but it significantly and dose-dependently shortened the median animal lifespan (Fig
In parallel, emerging data suggest that gut microbiota composition and its metabolites (notably short-chain fatty acids) display modest menstrual-phase-related variation and are associated with markers of dyslipidemia and dysbiosis, implying that microbiotahost interactions may further modulate lipid handling across the cycle, particularly in women with obesity or metabolic syndrome [121,126]
ALS exemplifies a profound axonal bioenergetic catastrophe, extending the principle of mitochondrial vulnerability to extreme demands of the motor system
Polverino de Laureto et al., 2002
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