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Factorial experimental designs with single-compound and combined-compound treatment arms, alongside vehicle controls, allow researchers to statistically distinguish independent compound effects from any combination-specific outcomes on NAD+ pathway and mitochondrial redox endpoints, a standard approach in multi-compound cellular metabolism research.

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145 The pectin coating protected the NPs during gastric transit and enabled localized release in the colon via microbial pectinase degradation, while collagen IV targeting enhanced NP adhesion to injured colonic tissues

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