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Taylor, J.A

5.0 Pharmacological properties 5.1 Mechanism of action Glutathione is an extremely important cell protectant which directly quenches reactive hydroxyl free radicals, other oxygen-centered free radicals, and radical centers on DNA and other biomolecules

Although overall, TNBCs expressed less PRLR detected with an antibody to the intracellular domain of the long PRLR (92), a subset of these tumors expressed higher PRLR levels

A study involving 30 patients with heart failure demonstrated that a 6-month chronic exercise intervention, comprising moderate-intensity treadmill exercise, resistance training, and stretching (90 min/session, 3 times/week), significantly reduced lipid and protein peroxidation, enhanced the activity of antioxidant enzymes CAT and SOD, and exerted anti-inflammatory effects, as evidenced by reductions in fibrinogen, C-reactive protein, and TNF- expression levels

Measurement of ROS Intracellular ROS and peroxidized lipid levels were determined using CM-H2DCFDA (C6827, Life Technologies, Grand Island, NY, USA) and BODIPY TM 581/591 C11 (D3861, Life Technologies), respectively

Design, synthesis, and evaluation of diazeniumdiolate-based DNA cross-linking agents activatable by glutathione S-transferase