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Therefore, metabolic remodeling or chronic inflammation induced by damaged tissues, cells, or biomolecules is considered a critical biological factor in the organismal aging process

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After treatment, brain tissues were harvested and evaluated for oxidative stress biomarkers (8-OHdG, MDA, GPx, GSH, GST, SOD), pro-inflammatory cytokines (MPO, NF-B, TNF-), ion transport enzymes (Na/K ATPase, Ca ATPase), neurotransmitter levels (dopamine, serotonin, AChE), and the apoptotic marker caspase-3

Because they are potentially harmful for cellular integrity, ROS and NO levels must be tightly controlled, especially by the classical antioxidant system and additional redox-active metabolites and proteins

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Glutathione supplements come in different forms, including capsules, powders, and IV drips