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bipolar disorder (BD)

Blood glutathione peroxidase activity in relation with the risk of cardiovascular diseases in obese women

This peroxidation occurs via two major pathways: the enzymatic pathway, mediated by lipoxygenases (LOXs), cytochrome P450 oxidoreductase (POR), and NADPH oxidases (NOXs), promotes the generation of PUFA-PL-OOHs, leading to the accumulation of reactive aldehydes, ketones, and other toxic metabolites, ultimately disrupting membrane integrity and triggering ferroptosis (Maheshwari, 2023)

Cyclical changes in E2 and P4 alter hypothalamicpituitaryadrenal (HPA) axis sensitivity, modifying cortisol dynamics, stress perception, and emotional reactivity across the cycle [56]

Participants were then treated with oral glycine supplementation for two weeks and reassessed

Arthritis Res Ther (2015) 17:302