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UW228 shows partial sensitivity to SMO inhibitors and transient suppression of GLI1, with resistance mechanisms involving SUFU downregulation or GLI2 amplification

References Chang, Chung-Hsun et al

High homocysteine could also mean you have an MTHFR gene mutation, which makes you less efficient at converting inactive folate to the active form of folate that breaks down homocysteine

The combined clinical safety database from more than 20 clinical trials with tesofensine now contains approximately 1,600 patients taking a therapeutic dose for up to a year, providing robust safety data