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Beim Probanden fehlen zentrale Enzyme wie GSTM1 vollstndig, andere wie GSTP1, NAT2, SULT1A1 und COMT sind nur eingeschrnkt aktiv

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The Diabetes Prevention Program Outcomes Study (DDPOS) showed that combined low and borderline-low vitamin B 12 levels were more common in metformin users after 5 and 13 years of use, compared with levels in non-users