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Other studies indicate that while stress may play a part, it is only a small part of a bigger picture where disease and other factors contribute

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Design, synthesis, and evaluation of diazeniumdiolate-based DNA cross-linking agents activatable by glutathione S-transferase

As for PDPN targeting, the relief of the inhibitory signal delivered through the CD47-SIRP- binding on macrophages could generate a pro-inflammatory TME favoring the anti-MB immune response, as indicated for other tumor types (287, 288)

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