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PDI oxidation by Ero1 leads to the production of ROS (Gross et al , 2006)

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Patients affected with Chronic Kidney Disease (CKD) or end-stage Stage Renal Disease (ESRD) experience a tremendous cardiovascular threat that may also further lead to death

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[95] observed that treatment of Shank3 4-22 mice with 7-NI (nNOS inhibitor) resulted in an increase in time spent in the open arms of the elevated plus maze and an enhancement in cognitive behavior, as measured by the novel object recognition test [95]

Peptides are complex, fragile molecules
