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doi: 10.1038/sj.ijo.0803265

Methylation Lab Testing A persons methylation status is influenced by diet and environment, but genetics is usually the dominant factor

The most well-studied mutations include: C677T Mutation: Individuals with one copy of this mutation (heterozygous) may have a 3040% reduction in MTHFR enzyme activity

H., Watkins P

Because MMR proteins form heterodimer pairs, a 4-antibody approach targeting all 4 proteins or a 2-antibody approach targeting only heterodimer partners PMS2 (which binds to MLH1 ) and MSH6 (which binds to MSH2 ) may be used.9 , 10 Tumour MSI and IHC testing have comparable performance