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For patients who have not achieved adequate glycemic control with existing medications or lifestyle modifications alone, GLP-1 therapy offers a potent alternative with greater potency and longer half-life compared to some other GLP-1 RA therapies

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Retatrutide clinical data shows modest improvements in cardiovascular markers, including blood pressure reductions averaging 6-8 mmHg

Easier to measure small doses precisely

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But many of the products have never been extensively studied in humans, raising concerns that they could cause allergic reactions, metabolic problems and other dangerous side effects