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In an animal model, daily GIP injections decreased proinflammatory cytokines (IL-6, interleukin-1, and TNF- ) while increasing lipocalin levels [40], while GLP-1 receptor activation upregulates the second messenger cyclic adenosine monophosphate (cAMP) and activates protein kinase A (PKA)

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Yet subcutaneous injections of recombinant GLP-1 were a disappointment in patients, falling short of prior results with intravenous GLP-1

CNODES, Canadian Network for Observational Drug Effect Studies

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