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These compounds will be quickly excreted when intake is in excess

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95% CI: 0.9466, 0.9956

Consistent with this, boosting shuttle activity (via overexpression of their enzymes) decreased lactate accumulation and diverted more glucose into citrate with no impairment of proliferation 186 , also in agreement with an earlier notion that the Warburg effect is a consequence of limited NADH-shuttle throughput rather than a driver of proliferation 187

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