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Healthy gut bacteria also play a key role in breaking down proteins, making digestive enzymes, and helping transport B12 with proteins like intrinsic factor and transcobalamin II

Discovery of gastric inhibitory polypeptide (GIP) Among those active in the field was John Brown (figure 16), a British-born physiologist, who developed a passion for the gastrointestinal gut while doing a doctorate at the University of Newcastle-upon-Type

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Alcohol & Smoking Both alcohol and cigarette smoke increases free radical production, leading to greater oxidative damage and a higher demand for glutathione

Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy

For example, the deletion of compo-nents of the glutathione detoxication system such as glutathione peroxidase (Mirochnitchenko et al ., 1999) and glutathione transferase-pi (GST-pi) (Henderson et al ., 2000) both afforded partial protection against paracetamol hepatotoxicity