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We demonstrated that Aldh2 KI mice carrying the East Asian-specific Glu504Lys mutation were more prone to develop diet-induced obesity, fatty liver, insulin resistance and glucose intolerance than WT mice Importantly, the ALDH2 activator AD-9308 increased both the catalytic activity of WT and mutant enzyme, reduced serum 4-HNE levels, and effectively alleviated diet-induced obesity, fatty liver, insulin resistance, and glucose intolerance in both Aldh2 KI and WT mice in a dose-dependent manner

Maurano, M

Volek, J

Impact of impaired methylation : Poor detoxification increases oxidative stress and inflammation in the thyroid gland, which can exacerbate conditions like Hashimotos thyroiditis and Graves disease

S.McGeeA

KRAS4A directly regulates hexokinase (HK) 1, which enhances glucose utilization in tumor cells and supports survival under metabolic stress [20]