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For patients with urticaria and flushing, H1-antihistamines such as diphenhydramine or promethazine are effective, and adding an H2-antihistamine like ranitidine may provide additional relief

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Thus, the genetic and metabolic characteristics of ccRCC cells affect their sensitivity to iron-mediated cell death, but more exploration of the relationship between intracellular iron levels and renal tumor progression is needed
