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Studies have shown that IGF-l and IGF1R mRNA expression in cultured young intervertebral disc cells is higher than that in mature cells, and the decrease of IGF-l dependent protein polysaccharide synthesis in rat NPCs is due to the downregulation of IGF-IR in late senescence (Osada et al., 1996

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Growth factor receptors mediating tissue repair Receptor tyrosine kinases (RTKs): Large family of cell surface receptors binding growth factors and triggering multiple signaling pathways