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Nanase (Cox-MION), a peroxidase-mimetic nanoconjugate, directly generates lipid peroxides through enzyme-like activity while its spherical structure mechanically suppresses tumor growth, achieving ~40% volume reduction in preclinical models [108]

10.1016/j.freeradbiomed.2019.07.005 [DOI] [PubMed] [Google Scholar] 49.Arts RJ, Novakovic B, Horst RT, Carvalho A, Bekkering S, Lachmandas E, et al

It also leads to the production of more free radicals (O 2 , ONOO , OH, and H 2 O 2 ) (Erejuwa, 2012), ROS production (Wu et al., 2018), and ultimately decrease glucose homeostasis and insulin sensitivity in the liver (Yang et al., 2010)

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and Low if L 2 or if evidence was available from only one source