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This enzyme corresponds to the non-heme thiol peroxidase family that utilizes either glutathione (GSH) or thioredoxin (Trx) as reducing substrates [197]

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567,568 For example, tannic acid could bind to the GPX4 activation site, enhancing its activity and cellular level, which in turn regulated amyloid and tau protein deposition by reducing oxidative stress and inhibiting ferroptosis, 569 providing a promising therapeutic avenue for combating the interaction between ferroptosis and AD