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Of note, female participation in Phase 3 trials has been higher relative to all trials in all reporting periods except for 2016 (the highest difference in relative representation of females was observed in 2013, where Phase 3 trials reported 64.2 percent females, while all trials reported just 44.3 percent females)

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Once released, mtDNA can be internalized into endolysosomal compartments through processes like phagocytosis, autophagy, or uptake of EVs [125, 126])

This leads to an enhancement in mitochondrial energy metabolism

Fensky, RPh

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