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Step 2 FDA Review of Recommendations: The FDA considers the panel's conclusions alongside internal review

Efficacy and safety of once-weekly cagrilintide for weight management: a randomised, placebo and active-controlled, dose-finding phase 2 trial

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For background on the broader angiotensin IV / AT4 system the work was built on, see Wright and Harding 1995 (PMID 7768321) and Wright et al

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demonstrated weight loss (15.4%) after 20 weeks of cagrilintide therapy (4.5 mg/week) in combination with semaglutide (2.4 mg/week) [89]