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The last NAC administration was given 2.5 h prior the behavioral experiments, as it has been demonstrated that glutamate levels were elevated in the rat brain approximately 2.5 h after NAC administration (48)

This interaction helps predict how advanced NSCLC patients will respond to anti-PD-1/PD-L1 immunotherapy, offering a new predictive biomarker [239]

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doi: 10.1016/j.tplants.2016.08.002 57 MittlerR.VanderauweraS.GolleryM.Van BreusegemF

These effects are likely to be mediated through the regulation of MG levels, as MG was demonstrated to act as a competitive partial agonist for GABAA (-aminobutyric acid A) receptors (Distler et al., 2014)

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