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Unlike pharmaceutical agents (e.g., statins) that carry side effects (e.g., myopathy), probiotics are generally safe and exert pleiotropic effects, including cholesterol lowering, anti-inflammation, and endothelial protection ( 2 PRISMA compliance and literature selection process 3 Gut microbiota dysbiosis and atherosclerosis: the mechanistic link Gut microbiota dysbiosis contributes to AS through three interconnected pathways: metabolic dysregulation, inflammatory activation, and vascular dysfunction ( Figure 1 )

Hemasphere 3 , e301 (2019)

The online software, VENNY v2.1 ( 16 was used to intersect the DEGs with all ferroptosis-related genes, redrawing the Venn Diagram with improved clarity and accuracy

The criteria renal injury was based on the degeneration of Bowmans space and glomeruli, degeneration of the proximal and distal tubules, vascular congestion, and interstitial edema (Strbe et al., 2021)

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IGF-1 LR3 also has a significantly longer half-life than IGF-1