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In certain embodiments of such auris-compatible formulations or compositions that comprise a dye, the ability to visualize a controlled release otic formulation or composition comprising a dye in an ear meets a long standing need for suitable testing methods that are applicable to the development of intratympanic otic formulations or compositions suitable for human use

The 5-day spacing between injections reflects the pharmacodynamics of how MOTS-c signals at the mitochondrial level

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10.1038/emm.2004.1 69 LesterS

Nrf2 is integral to cellular defenses against oxidative damage