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Apoptosis regulation is complex, involving multiple signaling pathways and target genes, including the B-cell lymphoma 2 (BCL-2) family of proteins, caspases, the tumor protein p53 (TP53), and inhibitors of apoptosis proteins (IAPs) [91]

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Supplementary Material Acknowledgments Funding This research was funded by the Center for Tobacco Products at the United States Food and Drug Administration (FDA)

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