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1 Introduction Cardiovascular disease (CVD) is the leading cause of morbidity and mortality, affecting over 523 million people globally, and CVD mortality rates are predominated by atherosclerotic diseases (Zhou and Wu, 2023)

Maximum results typically appear by week 12

Discher DE, Janmey P, Wang YL

The central mechanism involves both homeostatic (energy balance) and hedonic (food reward) pathways, providing comprehensive appetite regulation

(33) found that phenylalanine is important in the interaction between Lesinurad and other URAT1 inhibitors, which may be part of the inhibitor binding site in the URAT1 transporter channel, and URAT1 is responsible for the reabsorption of uric acid

When treated with H 2 O 2 (500 M, 2 h), GPx1-KD macrophages displayed increased cytotoxicity compared to cells treated with the nsSiRNA (Fig