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The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of subcutaneous adipose tissue in humans

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Exceeding these thresholds causes muscle distension and reduced absorption efficiency

When you stay within recommended doses, long-term use is considered safe for healthy adults

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Less common but more severe side effects include specific nutrient deficiencies, kidney stones, bone fractures and increased infections, which can be treated with standard therapies and appropriate vitamin and nutrient supplementation while maintaining the diet (70)