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10.1016/0022-510X(73)90118-4 31 BlakemoreW

The potential pathogenic mechanisms underlying IC/BPS are diverse and can include bladder immune dysregulation, abnormalities in the nociceptive system, urothelial barrier dysfunction and even alterations in bladder microorganisms

No findings suggest clinical relevance, therapeutic intent, or suitability for human or veterinary use

The receptor is then trafficked to clathrin-coated vesicles (CCVs) and internalized via endocytosis

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Finally, patients with IC/BPS with more documented areas of pain outside the pelvis and higher pain severity exhibited secondary hyperalgesia and central sensitization [70]