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Mechanistically, this shift from beneficial to detrimental involves sustained activation of NF-B and p38 MAPK pathways, elevated ROS production from dysfunctional mitochondria, and unresolved DNA damage response signaling

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Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response

Three patients had grade 1 or 2 neutropenia, 5 patients had grade 3 or 4 neutropenia, and anemia symptoms were mild 28 (Table 1)

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Together this prompted us to try a similar sequential treatment regimen of FOXO4-DRI in Doxorubicin-exposed mice in vivo