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Similar content being viewed by others Introduction Diabetes mellitus (DM) is a worldwide metabolic disease characterized by chronic hyperglycemia, which results from insufficient insulin secretion and/or insulin resistance in target tissues or both [1, 2]

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40 HulmeE.BirdsallN.BuckleyN
PR-104 showed linear pharmacokinetics, rapid conversion to PR-104A, and evidence of antitumor activity, including partial responses and prolonged stable disease in some patients (282)

Leucine metabolism in T cell activation: Mtor signaling and beyond
