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Nevertheless, some deficiencies should also be focused on: a large number of studies have shown that inorganic nanoparticles (titanium dioxide (Sun et al., 2012), gold, and silver (Kheiralla et al., 2014) can produce cytotoxic effects, promote the accumulation of ROS, and lead to lung inflammation

In this comment, we present major concerns and possible solutions in cell therapy for disc degeneration (Table 2)

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doi: 10.1016/j.pharep.2017.03.008

7 Conclusion In conclusion, ferroptosis bridges oxidative stress, iron overload, and lipid peroxidation-induced tissue damage in periodontitis, extending the classical infectioninflammation framework by contributing to host response dysregulation and tissue destruction