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Secondly, although we revealed the endogenous function of VGF in hyperglucagonemia of GCGR-KO cells, VGF polypeptides can be proteolytically cleaved into multiple bioactive peptides by prohormone convertases PC1/3 and PC2 49 , and some of these bioactive peptides, including TLQP-21, TLQP62 and NERP-4, have been confirmed to enhance the -cell function and attenuate the development of type 2 diabetes 50,51,52

The role of disulfide bounds in the stability of focal adhesion proteins are largely depicted in the control of cell surface receptors (reviewed in Hogg et al

To assess these genes further, the Search Tool for the Retrieval of Interacting Genes and proteins (STRING

doi: 10.1038/s41586-021-04025-w

Reprod Sci 20:12301236 Ermi IS, Deveci E, Ar F (2023) Effects of quince gel and hesperidin mixture on experimental endometriosis

doi: 10.1111/jog.12050