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The main physiological function of melatonin is to transfer information of the daily cycle of day and night to body systems to organize the functions that respond to photoperiod alteration which includes the cyclic rhythms

Maybe you're unable to participate in activities that bring joy, or you have a dependency on coffee and stimulants to make it through the day
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PKC activation increases the catalytic activity of 12/15-lipoxygenase toward PUFAs in neuronal membranes by phosphorylating it

doi: 10.1001/archinte.160.6.837