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Babault N, Allali-hassani A, Li F, Fan J, Yue A, Ju K, Liu F, VedadI M, Liu J, Jin J (2018) Discovery of bisubstrate inhibitors of nicotinamide N -methyltransferase (NNMT)

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Effect of intra-articular injection of AOD9604 with or without hyaluronic acid in rabbit osteoarthritis model

Route of Administration: Intramuscular (IM) injection, typically in the vastus lateralis muscle (thigh)

PMID: 25998928

With both compounds reducing energy intake (tirzepatide through appetite) and mobilizing stored energy (AOD 9604 through lipolysis), the body is working harder to maintain homeostasis