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Is retinal metabolic dysfunction at the center of the pathogenesis of age-related macular degeneration

It has been shown that both COVID-19 and PCC may be risk factors for long-term neurodegeneration, firstly due to chronic neuroinflammation of the neurovascular unit as we describe in Figure 2, but it may also be due to the fact that the SARS-CoV-2 nucleocapsid protein (N-protein) considerably speeds up the -synuclein aggregation process formation that leads to the formation of multiprotein complexes and eventually amyloid fibrils, which could increase the risk of triggering Parkinsons and Alzheimers disease [60]

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Doverty M, White JM, Somogyi AA, Bochner F, Ali R, Ling W

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Another polymorphism in the same gene is rs7194, which is associated with non-obstructive azoospermia [95]