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The observations that dsRNA is not merely an RNAi substrate and can activate signaling pathways as a PAMP and that Dcr-2 and Ago-2 are pleiotropic genes invite detailed analysis with respect to the effects of administration of dsRNA to insect pests and to what extent a bona fide RNAi mechanism is triggered

Kjrgaard K, Daugaard Mikkelsen AC, Landau AM, Eriksen PL, Hamilton-Dutoit S, Magnusson NE, Thomsen MB, Chen F, Vilstrup H, Mookerjee RP, et al

In order to gain insight into the antioxidant capacity of the cells tested, in our study we also controlled the level of sulfane sulfur, as well as the levels of low-molecular-weight, non-protein sulfur-containing compounds, such as the oxidized and reduced form of glutathione, cysteine ad cystine

Lant EC

2022 Jun;105(6):663-664

From anti-inflammatory study, it was demonstrated that, pro inflammatory cytokines expression was reduced significantly and blockage of IL-6/STAT3 pathway preserved after exposure of wedelolactone [130]