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Description
Before the use, we confirmed the liver humanization by the presence of human albumin (11.9 0.8 mg/mL) in the blood of PXB mice which were generated using human hepatocytes derived from a single donor

Because elevated homocysteine can be caused by a number of factors [68] and enzymatic confirmation of CBS deficiency is available in only a few laboratories worldwide, functional information from the VE map could enable clinical interpretation of pathogenicity and thus aid in clinical diagnosis

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GN: Conceptualization, Investigation, Project administration, Writing review & editing

H 2 S is produced in multiple cell types including cardiovascular endothelial cells, hepatocytes, pancreatic beta cells, enterocytes, and neurons via four enzymes: cystathionine -synthase (CBS), cystathionine -lyase (CTH or CSE), 3-mercaptopyruvate sulfurtransferase (3MST), and Selenium-Binding Protein 1 (SELENPB1) [10,11,12]

doi: 74
