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MDR was defined as acquired non-susceptibility to at least one agent in three or more antimicrobial categories, XDR was defined as non-susceptibility to at least one agent in all but two or fewer antimicrobial categories (i.e., bacterial isolates remain susceptible to only one or two categories), and PDR was defined as non-susceptibility to all agents in all antimicrobial categories 19

10.1186/1423-0127-17-S1-S23 J

10.1007/s00125-021-05618-w 205

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Increased nitric oxide production in lymphatic endothelial cells causes impairment of lymphatic drainage in cirrhotic rats