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Tesamorelin increases endogenous GH and IGF-1 levels, providing broader metabolic effects but also potential for glucose elevation and insulin resistance

Gut 64 (6), 872883

Given these features, it can be mistaken for chronic inflammatory demyelinating polyneuropathy (CIDP), and in fact, up to 60% of POEMS patients may be initially misdiagnosed with CIDP and receive CIDP-directed treatment [11]

They are also easy to process, quench and extract for further metabolomic analysis

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Since we did not detect a decrease in pyruvate in the cortex (Supplementary Table 7), these results could suggest there may be reduced lactate dehydrogenase activity in astrocytes, as lactate can be produced downstream from glucose to support energy needs in neurons