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Under the influence of thiolase (acetyl-CoA acetyltransferase 1, ACAT1), CoA-SH is detached from one molecule of acetyl-CoA, and acetoacetyl-CoA (AcAc-CoA) is formed

VPA is used to treat psychiatric disorders and as such there is an association with accidental or deliberate overdose, the incidence of which is increasing [135, 136]

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Impacting dementia and cognitive loss with innovative strategies: mechanistic target of rapamycin, clock genes, circular non-coding ribonucleic acids, and rho/rock