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3.2.2.2 Clinical studies At the clinical level, RCTs have been carried out to evaluate the effects of some GLP-MA in PD patients (Table 2) (Hlscher, 2024)

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48,49 The acute imbalance between the accumulation of ROS and antioxidant defence mechanisms results in OS, as previously described, and this is thought to have a principal role in the pathogenesis of Alzheimers disease, where imbalance promotes the expression of mitochondrial genes involved in metabolism and the ROS generated causes gene mutations in mitochondrial DNA
