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Lactylation of METTL16 promotes cuproptosis via m(6)A-modification on FDX1 mRNA in gastric cancer

Xiaoyaosan decreases the expression of purinergic ligand-gated ion channel 7 (P2X7) protein, inhibits the activation of the NLRP3 inflammasome, and reduces the levels of proinflammatory cytokines such as TNF-, IL-1, and IL-6 (Hao et al., 2021

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The result is 100% bioavailability at therapeutic concentrations that oral supplementation cannot achieve

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Precisely, ASM modulates the lysosomal nutrient-sensing complex (LYNUS), which integrate a mTOR and transcription factor EB (TFEB) mutual crosstalk