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An 18% increase in the mean cellular GSH level was achieved in cultures of the engineered strain supplemented with D-histidine to counter-select cells with high GAP1 expression (i.e

When exposed to oxidative stress like drugs, toxic chemicals, disease, aging, stress, glutathione levels drop

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Smoday I.M., Petrovic I., Kalogjera L., Vranes H., Zizek H., Krezic I., Gojkovic S., Skorak I., Hriberski K., Brizic I., et al

doi: 10.1203/PDR.0b013e318212f16b

It shows antioxidative properties and provides protection to cells against excessive ROS production, which prevents excessive oxidation of nucleic acids or lipid membrane peroxidation