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10.1016/j.ydbio.2014.03.023 8 BowmanA

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Hypoxia in these areas induces the expression of inflammatory molecules (IL-4, IL-10 et al.), thus promoting the recruitment of macrophages followed by conversion to the M2 phenotype [46]

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Continuous, daily usage without breaks is generally not recommended due to the lack of extensive human data and potential risks 1 2